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mouse model for lung metastases  (Charles River Laboratories)

 
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    Structured Review

    Charles River Laboratories mouse model for lung metastases
    Histological results of the lungs of mice in (A) control group with no p16 MIS peptide treatment (B) single p16 MIS peptide treatment group (p16×1) and (C) triple p16 MIS peptide treatment group (p16×3). Histological data of the lung at the 14th experimental day after MBT-2 administration via the mouse tail vein demonstrates that lung <t>metastases</t> are inhibited in number and size in the groups administered with the p16MIS peptide (B and C), compared with the control group (A). In the group with triple p16MIS peptide injection (C), metastases was rarely observed in the lung (magnification, ×40). Note that the arrows indicate metastatic nodules.
    Mouse Model For Lung Metastases, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+model+for+lung+metastases/mouse+model+for+lung+metastases/pmc06312983-96-3-12
    Average 90 stars, based on 1 article reviews
    mouse model for lung metastases - by Bioz Stars, 2026-09
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    Images

    1) Product Images from "Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice"

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice

    Journal: Oncology Letters

    doi: 10.3892/ol.2018.9655

    Histological results of the lungs of mice in (A) control group with no p16 MIS peptide treatment (B) single p16 MIS peptide treatment group (p16×1) and (C) triple p16 MIS peptide treatment group (p16×3). Histological data of the lung at the 14th experimental day after MBT-2 administration via the mouse tail vein demonstrates that lung metastases are inhibited in number and size in the groups administered with the p16MIS peptide (B and C), compared with the control group (A). In the group with triple p16MIS peptide injection (C), metastases was rarely observed in the lung (magnification, ×40). Note that the arrows indicate metastatic nodules.
    Figure Legend Snippet: Histological results of the lungs of mice in (A) control group with no p16 MIS peptide treatment (B) single p16 MIS peptide treatment group (p16×1) and (C) triple p16 MIS peptide treatment group (p16×3). Histological data of the lung at the 14th experimental day after MBT-2 administration via the mouse tail vein demonstrates that lung metastases are inhibited in number and size in the groups administered with the p16MIS peptide (B and C), compared with the control group (A). In the group with triple p16MIS peptide injection (C), metastases was rarely observed in the lung (magnification, ×40). Note that the arrows indicate metastatic nodules.

    Techniques Used: Control, Injection

    Number and size of lung metastases of MBT-2 cells control group and groups following p16 MIS peptide treatment. (A) Number of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. For the number of lung metastases, the significance for control vs. p16×1 or p16×3 was P=0.0087 and P=0.0029, respectively (B) Size of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. The significance for the area of metastases was P=0.0183 and P=0.0296 for control vs. p16×1 or p16×3, respectively. Quantitative evaluation demonstrated that the number (A) and size (B) of metastases in histological sections were statistically different between the p16 MIS peptide transduction and control groups. p16×1, single treatment of p16 MIS peptide; p16×3, triple treatments of p16 MIS peptide.
    Figure Legend Snippet: Number and size of lung metastases of MBT-2 cells control group and groups following p16 MIS peptide treatment. (A) Number of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. For the number of lung metastases, the significance for control vs. p16×1 or p16×3 was P=0.0087 and P=0.0029, respectively (B) Size of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. The significance for the area of metastases was P=0.0183 and P=0.0296 for control vs. p16×1 or p16×3, respectively. Quantitative evaluation demonstrated that the number (A) and size (B) of metastases in histological sections were statistically different between the p16 MIS peptide transduction and control groups. p16×1, single treatment of p16 MIS peptide; p16×3, triple treatments of p16 MIS peptide.

    Techniques Used: Control, Transduction

    Histological findings of H&E staining, phosphorylated Rb immunohistochemistry and TUNEL staining in lung metastasis of control and p16 MIS peptide treatment group. (A) H&E staining of control group. (B) Phosphorylated Rb immunostaining of control group. (C) TUNEL staining of control group. (D) H&E staining of p16 MIS peptide treatment group. (E) Phosphorylated Rb immunostaining of p16 MIS peptide treatment group. (F) TUNEL staining of p16 MIS peptide treatment group. Rb phosphorylation decreased in p16 MIS peptide treatment group (E) compared with control group (B). In TUNEL staining, apoptosis was detected in p16 MIS peptide treatment group (F) compared with control group (C). Magnification, ×400. H&E, hematoxylin and eosin.
    Figure Legend Snippet: Histological findings of H&E staining, phosphorylated Rb immunohistochemistry and TUNEL staining in lung metastasis of control and p16 MIS peptide treatment group. (A) H&E staining of control group. (B) Phosphorylated Rb immunostaining of control group. (C) TUNEL staining of control group. (D) H&E staining of p16 MIS peptide treatment group. (E) Phosphorylated Rb immunostaining of p16 MIS peptide treatment group. (F) TUNEL staining of p16 MIS peptide treatment group. Rb phosphorylation decreased in p16 MIS peptide treatment group (E) compared with control group (B). In TUNEL staining, apoptosis was detected in p16 MIS peptide treatment group (F) compared with control group (C). Magnification, ×400. H&E, hematoxylin and eosin.

    Techniques Used: Staining, Immunohistochemistry, TUNEL Assay, Control, Immunostaining, Phospho-proteomics

    Related Articles

    Control:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Injection:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Transduction:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Staining:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Immunohistochemistry:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    TUNEL Assay:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Immunostaining:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Phospho-proteomics:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0

    Light Microscopy:

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice
    Article Snippet: of p16 in MBT-2 and that restoration of p16 function by peptide transduction resulted in downregulation of phosphorylated Rb expression ( 6 ). .. Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan). .. The mice were kept under the following housing condition: 23.5±2.5°C temperature; 52.5±12.5% humidity; 200Lx illumination during daytime (5:00 to 19:0



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    mouse model for lung metastases  (Charles River Laboratories)
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    Charles River Laboratories mouse model for lung metastases
    Histological results of the lungs of mice in (A) control group with no p16 MIS peptide treatment (B) single p16 MIS peptide treatment group (p16×1) and (C) triple p16 MIS peptide treatment group (p16×3). Histological data of the lung at the 14th experimental day after MBT-2 administration via the mouse tail vein demonstrates that lung <t>metastases</t> are inhibited in number and size in the groups administered with the p16MIS peptide (B and C), compared with the control group (A). In the group with triple p16MIS peptide injection (C), metastases was rarely observed in the lung (magnification, ×40). Note that the arrows indicate metastatic nodules.
    Mouse Model For Lung Metastases, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/mouse+model+for+lung+metastases/mouse+model+for+lung+metastases/pmc06312983-96-3-12
    Average 90 stars, based on 1 article reviews
    mouse model for lung metastases - by Bioz Stars, 2026-09
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    Image Search Results


    Histological results of the lungs of mice in (A) control group with no p16 MIS peptide treatment (B) single p16 MIS peptide treatment group (p16×1) and (C) triple p16 MIS peptide treatment group (p16×3). Histological data of the lung at the 14th experimental day after MBT-2 administration via the mouse tail vein demonstrates that lung metastases are inhibited in number and size in the groups administered with the p16MIS peptide (B and C), compared with the control group (A). In the group with triple p16MIS peptide injection (C), metastases was rarely observed in the lung (magnification, ×40). Note that the arrows indicate metastatic nodules.

    Journal: Oncology Letters

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice

    doi: 10.3892/ol.2018.9655

    Figure Lengend Snippet: Histological results of the lungs of mice in (A) control group with no p16 MIS peptide treatment (B) single p16 MIS peptide treatment group (p16×1) and (C) triple p16 MIS peptide treatment group (p16×3). Histological data of the lung at the 14th experimental day after MBT-2 administration via the mouse tail vein demonstrates that lung metastases are inhibited in number and size in the groups administered with the p16MIS peptide (B and C), compared with the control group (A). In the group with triple p16MIS peptide injection (C), metastases was rarely observed in the lung (magnification, ×40). Note that the arrows indicate metastatic nodules.

    Article Snippet: Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan).

    Techniques: Control, Injection

    Number and size of lung metastases of MBT-2 cells control group and groups following p16 MIS peptide treatment. (A) Number of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. For the number of lung metastases, the significance for control vs. p16×1 or p16×3 was P=0.0087 and P=0.0029, respectively (B) Size of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. The significance for the area of metastases was P=0.0183 and P=0.0296 for control vs. p16×1 or p16×3, respectively. Quantitative evaluation demonstrated that the number (A) and size (B) of metastases in histological sections were statistically different between the p16 MIS peptide transduction and control groups. p16×1, single treatment of p16 MIS peptide; p16×3, triple treatments of p16 MIS peptide.

    Journal: Oncology Letters

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice

    doi: 10.3892/ol.2018.9655

    Figure Lengend Snippet: Number and size of lung metastases of MBT-2 cells control group and groups following p16 MIS peptide treatment. (A) Number of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. For the number of lung metastases, the significance for control vs. p16×1 or p16×3 was P=0.0087 and P=0.0029, respectively (B) Size of lung metastases in control group and groups with single and triple p16 MIS peptide treatment. The significance for the area of metastases was P=0.0183 and P=0.0296 for control vs. p16×1 or p16×3, respectively. Quantitative evaluation demonstrated that the number (A) and size (B) of metastases in histological sections were statistically different between the p16 MIS peptide transduction and control groups. p16×1, single treatment of p16 MIS peptide; p16×3, triple treatments of p16 MIS peptide.

    Article Snippet: Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan).

    Techniques: Control, Transduction

    Histological findings of H&E staining, phosphorylated Rb immunohistochemistry and TUNEL staining in lung metastasis of control and p16 MIS peptide treatment group. (A) H&E staining of control group. (B) Phosphorylated Rb immunostaining of control group. (C) TUNEL staining of control group. (D) H&E staining of p16 MIS peptide treatment group. (E) Phosphorylated Rb immunostaining of p16 MIS peptide treatment group. (F) TUNEL staining of p16 MIS peptide treatment group. Rb phosphorylation decreased in p16 MIS peptide treatment group (E) compared with control group (B). In TUNEL staining, apoptosis was detected in p16 MIS peptide treatment group (F) compared with control group (C). Magnification, ×400. H&E, hematoxylin and eosin.

    Journal: Oncology Letters

    Article Title: Systemic transduction of p16 INK4a antitumor peptide inhibits lung metastasis of the MBT-2 bladder tumor cell line in mice

    doi: 10.3892/ol.2018.9655

    Figure Lengend Snippet: Histological findings of H&E staining, phosphorylated Rb immunohistochemistry and TUNEL staining in lung metastasis of control and p16 MIS peptide treatment group. (A) H&E staining of control group. (B) Phosphorylated Rb immunostaining of control group. (C) TUNEL staining of control group. (D) H&E staining of p16 MIS peptide treatment group. (E) Phosphorylated Rb immunostaining of p16 MIS peptide treatment group. (F) TUNEL staining of p16 MIS peptide treatment group. Rb phosphorylation decreased in p16 MIS peptide treatment group (E) compared with control group (B). In TUNEL staining, apoptosis was detected in p16 MIS peptide treatment group (F) compared with control group (C). Magnification, ×400. H&E, hematoxylin and eosin.

    Article Snippet: Mouse model for lung metastases Six-week-old female C3H/He mice were obtained from Charles River Laboratories Japan, Inc. (Yokohama, Japan).

    Techniques: Staining, Immunohistochemistry, TUNEL Assay, Control, Immunostaining, Phospho-proteomics